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KMID : 1103920120180010084
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Korean Journal of Hepatology
2012 Volume.18 No. 1 p.84 ~ p.88
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Drug rash with eosinophilia and systemic symptoms syndrome following cholestatic hepatitis A: a case report
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An Ji-Hyun
Lee Joo-Ho
Lee Hyo-Jeong
Yu Eun-Sil
Lee Dan-Bi
Shim Ju-Hyun
Yoon Sun-Young
Lee Yu-Mi
Park So-Eun
Lee Han-Chu
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Abstract
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Hepatitis A virus (HAV) infections occur predominantly in children, and are usually self-limiting. However, 75-95% of the infections in adults are symptomatic (mostly with jaundice), with the illness symptoms usually persisting for a few weeks. Atypical manifestations include relapsing hepatitis, prolonged cholestasis, and complications involving renal injury. Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, drug-induced hypersensitivity reaction characterized by skin rash, fever, lymph-node enlargement, and internal organ involvement. We describe a 22-year-old male who presented with acute kidney injury and was diagnosed with prolonged cholestatic hepatitis A. The patient also developed DRESS syndrome due to antibiotic and/or antiviral treatment. To our knowledge, this is the first report of histopathologically confirmed DRESS syndrome due to antibiotic and/or antiviral treatment following HAV infection with cholestatic features and renal injury.
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KEYWORD
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Hepatitis A, Drug hypersensitivity, DRESS syndrome, Acute kidney injury
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